African American Specific Gene Panel Predictive of Poor Prostate Cancer Outcome.

ABSTRACT:

Purpose

Most prostate cancer in African American men lacks the ETS (E26 transforming specific) family fusion event (ETS-). We aimed to establish clinically relevant biomarkers in African American men by studying ETS dependent gene expression patterns to identified race specific genes predictive of outcomes.

Materials and methods

Two multicenter cohorts of a total of 1,427 men were used for the discovery and validation (635 and 792 men, respectively) of race specific predictive biomarkers. We used false discovery rate adjusted q values to identify race and ETS dependent genes which were differentially expressed in African American men who experienced biochemical recurrence within 5 years. Principal component modeling along with survival analysis was done to assess the accurac

SUBMITTER: Echevarria MI 

PROVIDER: S-EPMC7882398 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature