Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies.

ABSTRACT: Muscular dystrophies are a group of highly disabling disorders that share degenerative muscle weakness and wasting as common symptoms. To date, there is not an effective cure for these diseases. In the last years, bioengineered tissues have emerged as powerful tools for preclinical studies. In this review, we summarize the recent technological advances in skeletal muscle tissue engineering. We identify several ground-breaking techniques to fabricate in vitro bioartificial muscles. Accumulating evidence shows that scaffold-based tissue engineering provides topographical cues that enhance the viability and maturation of skeletal muscle. Functional bioartificial muscles have been developed using human myoblasts. These tissues accurately responded to electrical and biological stimulatio

SUBMITTER: Fernandez-Costa JM 

PROVIDER: S-EPMC7882756 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature