Identifying critical protein-coding genes and long non-coding RNAs in non-functioning pituitary adenoma recurrence.

ABSTRACT: Non-functioning pituitary adenoma (NFPA) is a very common type of intracranial tumor. Monitoring and predicting the postoperative recurrence of NFPAs is difficult, as these adenomas do not present with serum hormone hypersecretion. Long non-coding RNAs (lncRNAs) and protein-coding genes (PCGs) play critical roles in the development and progression of numerous tumors. However, the complex network of RNA interactions related to the mechanisms underlying the postoperative recurrence of NFPA is still unclear. In the present study, 73 patients with NFPA were investigated using high-throughput sequencing and follow-up investigations. In total, 6 of these patients with recurrence within 1 year after surgery were selected as the fast recurrence group, and 6 patients with recurrence 5 years after s

SUBMITTER: Guo J 

PROVIDER: S-EPMC7882882 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature