An independent poor-prognosis subtype of hepatocellular carcinoma based on the tumor microenvironment.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a highly malignant tumor with a particularly poor prognosis. The tumor microenvironment (TME) is closely associated with tumorigenesis, progression, and treatment. However, the relationship between TME genes and HCC patient prognosis is poorly understood.

Methods

In this study, we identified two prognostic subtypes based on the TME using data from The Cancer Genome Atlas and Gene Expression Omnibus. The Microenvironment Cell Populations-counter method was used to evaluate immune cell infiltration in HCC. Differentially expressed genes between molecular subtypes were calculated with the Limma package, and clusterProfiler was used for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analyses to identif

SUBMITTER: Wang J 

PROVIDER: S-EPMC7883156 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature