Innate immune evasion mediated by picornaviral 3C protease: Possible lessons for coronaviral 3C-like protease?

ABSTRACT: Severe acute respiratory syndrome coronavirus-2 is the etiological agent of the ongoing pandemic of coronavirus disease-2019, a multi-organ disease that has triggered an unprecedented global health and economic crisis. The virally encoded 3C-like protease (3CL^pro ), which is named after picornaviral 3C protease (3C^pro ) due to their similarities in substrate recognition and enzymatic activity, is essential for viral replication and has been considered as the primary drug target. However, information regarding the cellular substrates of 3CL^pro and its interaction with the host remains scarce, though recent work has begun to shape our understanding more clearly. Here we summarized and compared the mechanisms by which picornaviruses and coronaviruses have evol

SUBMITTER: Ng CS 

PROVIDER: S-EPMC7883238 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature