Association between prenatal immune phenotyping and cord blood leukocyte telomere length in the PRISM pregnancy cohort.

ABSTRACT:

Background

Environmental exposures including air pollutants, toxic metals, and psychosocial stress have been associated with shorter telomere length (TL) in newborns. These exposures have in turn been linked to an enhanced inflammatory immune response. Increased inflammation during pregnancy may be a central biological pathway linking environmental factors with reduced TL at birth. Approaches that more comprehensively characterize the prenatal inflammatory milieu rather than targeting specific individual cytokines in relation to newborn TL may better elucidate inflammatory mechanisms.

Methods

Analyses included 129 mother-child dyads enrolled in the PRogramming of Intergenerational Stress Mechanisms (PRISM) pregnancy cohort. We measured 92 inflammation related proteins during

SUBMITTER: Colicino E 

PROVIDER: S-EPMC7883408 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature