Genetic variants and physical activity interact to affect bone density in Hispanic children.

ABSTRACT:

Background

Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study.

Methods

Physical activity and dietary intake were measured by accelerometers and multiple-pass 24 h dietary recalls, respectively. Total body and lumbar spine BMD were measured by dual energy X-ray absorptiometry. A polygenic risk score (PRS) was computed based on SNPs identified in published literature. Regression analysis was conducted with PRSs, MVPA and calcium intake with total body and lumbar spine BMD.

Results

We found evidence of statistically significant interaction effects be

SUBMITTER: Hou R 

PROVIDER: S-EPMC7883422 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature