Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.

ABSTRACT: Aiming to uncover a shared genetic basis of abdominal obesity and osteoporosis, we performed a bivariate GWAS meta-analysis of femoral neck BMD (FNK-BMD) and trunk fat mass adjusted by trunk lean mass (TFM_adj) in 11,496 subjects from 6 samples, followed by in silico replication in the large-scale UK Biobank (UKB) cohort. A series of functional investigations were conducted on the identified variants. Bivariate GWAS meta-analysis identified two novel pleiotropic loci 12q15 (lead SNP rs73134637, p = 3.45 × 10^-7) and 10p14 (lead SNP rs2892347, p = 2.63 × 10^-7) that were suggestively associated and that were replicated in the analyses of related traits in the UKB sample (osteoporosis p = 0.06 and 0.02, BMI p = 0.03 and 4.61 × 10^-3, N up to 499,520).

SUBMITTER: Liu L 

PROVIDER: S-EPMC7883472 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature