Single-Cell Transcriptomic Reveals Dual and Multi-Transmitter Use in Neurons Across Metazoans.

ABSTRACT: Neurotransmitter expression is widely used as a criterion for classifying neurons. It was initially thought that neurons express a single type of neurotransmitter, a phenomenon commonly recognized as Dale's principle: "one neuron, one transmitter." Consequently, the expression of a single neurotransmitter should determine stable and distinguishable neuronal characteristics. However, this notion has been largely challenged and increasing evidence accumulates supporting a different scenario: "one neuron, multiple neurotransmitters." Single-cell transcriptomics provides an additional path to address coexpression of neurotransmitters, by investigating the expression of genes involved in the biosynthesis and transmission of fast-acting neuromodulators. Here, we study neuronal phenotypes based o

SUBMITTER: Brunet Avalos C 

PROVIDER: S-EPMC7883486 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature