Prognostic impact of lymphovascular invasion in pT1-T3 gallbladder adenocarcinoma.

ABSTRACT:

Background

Most gallbladder cancers are diagnosed after cholecystectomy for presumed benign disease, and nodal staging to inform subsequent treatment is therefore often lacking. We evaluated the association of lymphovascular invasion (LVI) with regional lymph node involvement in gallbladder adenocarcinoma and its impact on survival.

Methods

The National Cancer Database was queried to identify patients with resected gallbladder adenocarcinoma and with available staging and LVI status. Patients with pT4 and M1 disease were excluded. Univariable and multivariable regression identified factors associated with positive lymph nodes. Cox proportional hazards model was used to evaluate overall survival (OS).

Results

Of 1649 patients with available LVI status, 1142 (69.7%) had

SUBMITTER: Dominguez DA 

PROVIDER: S-EPMC7883507 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature