Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis.

ABSTRACT: Aiming to identify pleiotropic genomic loci for bone mineral density and bone size, we performed a bivariate GWAS in five discovery samples and replicated in two large-scale samples. We identified 2 novel loci at 2q37.1 and 6q26. Our findings provide insight into common genetic architecture underlying both traits.

Introduction

Bone mineral density (BMD) and bone size (BS) are two important factors that contribute to the development of osteoporosis and osteoporotic fracture. Both BMD and BS are highly heritable and they are genetically correlated. In this study, we aim to identify pleiotropic loci associated with BMD and BS.

Methods

We conducted a bivariate genome-wide association (GWA) analysis of hip BMD and hip BS in 6180 participants from 5 samples, followed by in silico r

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7883523 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature