SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.

ABSTRACT: Sirtuins are NAD⁺ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins. Modulation of sirtuins can thus be utilized as a therapeutic target for metabolic disorders. Neurological diseases have distinct clinical manifestations but are mainly age-associated and due to loss of protein homeostasis. Sirtuins mediate several life extension pathways and brain functions that may allow therapeutic intervention for age-related diseases. There is compelling evidence to support the fact that SIRT1 and SIRT2 are shuttled between the nucleus and cytoplasm and perform context-dependent functions in neurodegener

SUBMITTER: Manjula R 

PROVIDER: S-EPMC7883599 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature