Microbiomics of irrigation with xylitol or Lactococcus lactis in chronic rhinosinusitis.

ABSTRACT:

Objective

Topical sinonasal rinse therapies may alter the local microbiome and improve disease control in chronic rhinosinusitis (CRS). The objective of this study was to examine microbiome changes in post-surgical CRS patients when rinsing with commercially available products containing xylitol or Lactococcus lactis.

Methods

A crossover-type protocol with a washout period was designed. Swab samples from anterior ethmoid cavities of CRS patients were collected prospectively at baseline. Subjects were provided packets containing either L. lactis W136 or xylitol in non-blinded fashion and instructed to add it to their rinse bottles daily for 28 days, after which another swab was taken. A saline wash-out period was completed and a third swab taken. A final 28-day

SUBMITTER: Lambert PA 

PROVIDER: S-EPMC7883620 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature