Prognostic implications of cell division cycle protein 45 expression in hepatocellular carcinoma.

ABSTRACT:

Background

The overall prognosis of hepatocellular carcinoma (HCC) is poor and novel prognostic biomarkers might better monitor the progression of HCC. Cell division cycle protein 45 (CDC45) plays a key role in DNA replication and considered to be involved in tumorigenesis. This study investigated CDC45 expression in tumour tissues and defined its prognostic value in HCC patients.

Methods

We used immunohistochemistry (IHC) staining to examine the expression of CDC45 in tumour tissue specimens and compare them with adjacent normal tissue specimens using a constructed tissue microarray (TMA) and analyzed how clinical features are related to HCC prognosis. Functional enrichment analyses were used to describe significantly involved hallmark pathways of differentially expressed g

SUBMITTER: Yang C 

PROVIDER: S-EPMC7883691 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature