Extent of radiological response does not reflect survival in primary central nervous system lymphoma.

ABSTRACT:

Background

In primary central nervous system lymphoma (PCNSL), small enhancing lesions can persist after treatment. It is unknown whether a difference in response category (complete response [CR], complete response unconfirmed [CRu], or partial response [PR]) reflects survival. We aimed to determine the value of a central radiology review on response assessment and whether the extent of response influenced progression-free and/or overall survival.

Methods

All patients in the HOVON 105/ALLG NHL 24 study with at least a baseline MRI and one MRI made for response evaluation available for central review were included. Tumor measurements were done by 2 independent central reviewers, disagreements were adjudicated by a third reviewer. Crude agreement and interobserver agreement (C

SUBMITTER: van der Meulen M 

PROVIDER: S-EPMC7883767 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature