Survival and associated risk factors for mortality among infants with persistent pulmonary hypertension of the newborn in Malaysia.

ABSTRACT:

Objective

This study aims to determine the immediate outcome of persistent pulmonary hypertension of the newborn (PPHN) and risk factors for mortality in the era of inhaled nitric oxide (iNO).

Study design

This observational cross-sectional study includes 195 confirmed PPHN with a gestational age of ≥34 weeks without congenital heart disease. Multivariable logistic regression was used to identify risk factors for mortality.

Results

The mortality rate was 16.4%, with the highest mortality with pulmonary hypoplasia. Of 195, 65% received iNO; 18% were iNO non-responders with the majority having pulmonary hypoplasia. Independent risk factors for mortality were the presence of reversal of flow at the descending aorta, pulmonary hypoplasia, APGAR scores ≤ 5 at 5 min, and id

SUBMITTER: Mat Bah MN 

PROVIDER: S-EPMC7883964 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature