Enzyme-Functionalized Cellulose Beads as a Promising Antimicrobial Material.

ABSTRACT: The extensive use of antibiotics over the last decades is responsible for the emergence of multidrug-resistant (MDR) microorganisms that are challenging health care systems worldwide. The use of alternative antimicrobial materials could mitigate the selection of new MDR strains by reducing antibiotic overuse. This paper describes the design of enzyme-based antimicrobial cellulose beads containing a covalently coupled glucose oxidase from Aspergillus niger (GOx) able to release antimicrobial concentrations of hydrogen peroxide (H₂O₂) (≈ 1.8 mM). The material preparation was optimized to obtain the best performance in terms of mechanical resistance, shelf life, and H₂O₂ production. As a proof of concept, agar inhibition halo assays (Kirby-Ba

SUBMITTER: Califano D 

PROVIDER: S-EPMC7884000 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature