Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.

ABSTRACT: Cellular senescence is characterized by an irreversible cell cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP), which is a major contributor to aging and age-related diseases. Clearance of senescent cells has been shown to improve brain function in mouse models of neurodegenerative diseases. However, it is still unknown whether senescent cell clearance alleviates cognitive dysfunction during the aging process. To investigate this, we first conducted single-nuclei and single-cell RNA-seq in the hippocampus from young and aged mice. We observed an age-dependent increase in p16^Ink4a senescent cells, which was more pronounced in microglia and oligodendrocyte progenitor cells and characterized by a SASP. We then aged INK-ATTAC mice, in which p16

SUBMITTER: Ogrodnik M 

PROVIDER: S-EPMC7884042 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature