Serum Metabolites as an Indicator of Developing Gestational Diabetes Mellitus Later in the Pregnancy: A Prospective Cohort of a Chinese Population.

ABSTRACT:

Objective

Gestational diabetes mellitus (GDM) is a common metabolic disorder with onset during pregnancy. However, the etiology and pathogenesis of GDM have not been fully elucidated. In this study, we used a metabolomics approach to investigate the relationship between maternal serum metabolites and GDM in early pregnancy.

Methods

A nested case-control study was performed. To establish an early pregnancy cohort, pregnant women in early pregnancy (10-13⁺⁶ weeks) were recruited. In total, 51 patients with GDM and 51 healthy controls were included. Serum samples were analyzed using an untargeted high-performance liquid chromatography mass spectrometry metabolomics approach. The relationships between metabolites and GDM were analyzed by an orthogonal partial least-sq

SUBMITTER: Tian M 

PROVIDER: S-EPMC7884125 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature