Alterations in Functional Connectomics Associated With Neurocognitive Changes Following Glioma Resection.

ABSTRACT:

Background

Decline in neurocognitive functioning (NCF) often occurs following brain tumor resection. Functional connectomics have shown how neurologic insults disrupt cerebral networks underlying NCF, though studies involving patients with brain tumors are lacking.

Objective

To investigate the impact of brain tumor resection upon the connectome and relationships with NCF outcome in the early postoperative period.

Methods

A total of 15 right-handed adults with left perisylvian glioma underwent resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological assessment before and after awake tumor resection. Graph theoretical analysis was applied to rs-fMRI connectivity matrices to calculate network properties. Network properties and NCF measures wer

SUBMITTER: Noll KR 

PROVIDER: S-EPMC7884148 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature