Vitamin D-A New Perspective in Treatment of Cerebral Vasospasm.

ABSTRACT:

Background

Cerebral vasospasm (CVS) is a frequent complication after subarachnoid hemorrhage (SAH), with no sufficient therapy and a complex pathophysiology.

Objective

To explore the vitamin D system as a potential treatment for CVS.

Methods

25-vitamin D3 levels tested between 2007 and 2015 and data of SAH patients admitted during the months with a peak vs nadir of VitD3 values were analyzed, retrospectively. We prospectively correlated VitD3 and vasospasm/outcome data in SAH patients admitted in 2017. An experimental mice SAH model and cell culture model were used to investigate the effect of 1,25-dihydroxyvitamin D3 (1,25-VitD3). Additionally, the mediators acting in the VitD mechanism were researched and detected.

Results

Based on the retrospective analysis

SUBMITTER: Kashefiolasl S 

PROVIDER: S-EPMC7884149 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature