Longitudinal Testing of Retinal Blood Flow in a Mouse Model of Hypertension by Laser Speckle Flowgraphy.

ABSTRACT:

Purpose

The purpose of this study was to investigate the applicability of laser speckle flowgraphy (LSFG) for a longitudinal study of blood flow parameters in mice before, during, and after continuous infusion of angiotensin-II.

Methods

Normotensive C57BL/6J mice were imaged by LSFG at one (n = 22) or three sessions (n = 10). Two additional cohorts were imaged by LSFG before, during, and after continuous infusion of angiotensin-II by minipump for 2 or 4 weeks (n = 6 and 8, respectively). Retinal blood flow, vascular resistance, and total area of retinal vascular flow, a surrogate of vascular remodeling and vasoconstriction, were determined at each time point.

Results

During infusion of angiotensin-II for 2 weeks, decreased retinal blood flow and area of vascular flow,

SUBMITTER: Tamplin MR 

PROVIDER: S-EPMC7884297 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature