RegX3-Mediated Regulation of Methylcitrate Cycle in Mycobacterium smegmatis.

ABSTRACT: Mycobacterium tuberculosis is a global human pathogen that infects macrophages and can establish a latent infection. Emerging evidence has established the nutrients metabolism as a key point to study the pathogenesis of M. tuberculosis and host immunity. It was reported that fatty acids and cholesterol are the major nutrient sources of M. tuberculosis in the period of infection. However, the mechanism by which M. tuberculosis utilizes lipids for maintaining life activities in nutrient-deficiency macrophages is poorly understood. Mycobacterium smegmatis is fast-growing and generally used to study its pathogenic counterpart, M. tuberculosis. In this work, we found that the phosphate sensing regulator RegX3 of M. smegmatis is required for its g

SUBMITTER: Pei JF 

PROVIDER: S-EPMC7884335 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature