Advances in Human Immune System Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy.

ABSTRACT: Immunotherapy has established itself as a promising tool for cancer treatment. There are many challenges that remain including lack of targets and some patients across various cancers who have not shown robust clinical response. One of the major problems that have hindered the progress in the field is the dearth of appropriate mouse models that can reliably recapitulate the complexity of human immune-microenvironment as well as the malignancy itself. Immunodeficient mice reconstituted with human immune cells offer a unique opportunity to comprehensively evaluate immunotherapeutic strategies. These immunosuppressed and genetically modified mice, with some overexpressing human growth factors, have improved human hematopoietic engraftment as well as created more functional immune cell develop

SUBMITTER: Mian SA 

PROVIDER: S-EPMC7884350 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature