Loss of the orphan nuclear receptor NR2F6 enhances CD8⁺ T-cell memory via IFN-γ.

ABSTRACT: Memory formation is a hallmark of T cell-mediated immunity, but how differentiation into either short-lived effector cells (SLECs, CD127^-KLRG1⁺) or memory precursors cells (MPECs, CD127⁺KLRG1^-) and subsequent regulation of long-term memory is adjusted is incompletely understood. Here, we show that loss of the nuclear orphan receptor NR2F6 in germ-line Nr2f6-deficient mice enhances antigen-specific CD8⁺ memory formation up to 70 days after bacterial infection with Listeria monocytogenes (LmOVA) and boosts inflammatory IFN-γ, TNFα, and IL-2 cytokine recall responses. Adoptive transfer experiments using Nr2f6^-/- OT-I T-cells showed that the augmented memory formation is CD8⁺ T-cell intrinsic. Although the relative di

SUBMITTER: Jakic B 

PROVIDER: S-EPMC7884426 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature