Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration.

ABSTRACT: The application of physical stimuli to cell cultures has shown potential to modulate multiple cellular functions including migration, differentiation and survival. However, the relevance of these in vitro models to future potential extrapolation in vivo depends on whether stimuli can be applied "externally", without invasive procedures. Here, we report on the fabrication and exploitation of dynamic additive-manufactured Janus scaffolds that are activated on-command via external application of ultrasounds, resulting in a mechanical nanovibration that is transmitted to the surrounding cells. Janus scaffolds were spontaneously formed via phase-segregation of biodegradable polycaprolactone (PCL) and polylactide (PLA) blends during the manufacturing process and behave as ultrasound transducers

SUBMITTER: Camarero-Espinosa S 

PROVIDER: S-EPMC7884435 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature