Functionally Competent, PD-1⁺ CD8⁺ Trm Cells Populate the Brain Following Local Antigen Encounter.

ABSTRACT: Expression of programmed cell death-1 receptor (PD-1) has traditionally been linked to T-cell exhaustion, as signaling via PD-1 dampens the functionality of T-cells upon repetitive antigen exposures during chronic infections. However, resent findings pointing to the involvement of PD-1 both in T-cell survival and in restraining immunopathology, challenge the concept of PD-1 solely as marker for T-cell exhaustion. Tissue resident memory T cells (Trms) hold unique effector qualities, but within a delicate organ like the CNS, these protective abilities could potentially be harmful. In contrast to their counterparts in many other tissues, brain derived CD8⁺ Trms have been found to uniformly and chronically express PD-1. In this study we utilized a recently established model s

SUBMITTER: Scholler AS 

PROVIDER: S-EPMC7884456 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature