Infiltrating T-cell markers in cervical carcinogenesis: a systematic review and meta-analysis.

ABSTRACT:

Background

The host adaptive immune response helps determine which cervical HPV infections persist and progress to precancer and cancer, and systematic characterisation of T-cell infiltration would help inform key steps in cervical carcinogenesis.

Methods

A systematic review and meta-analysis were conducted of infiltrating T-cells in normal cervix, low-grade lesions, high-grade lesions, and invasive cancers including epithelial, stromal, and total tissue and the following markers: CD3, CD4, CD8, FoxP3, CD25, and the CD4:CD8 ratio. An additional qualitative review summarised longitudinal data on associations between infiltrating T-cells and cervical disease persistence, regression, progression, or prognosis.

Results

There were fewer CD3+, CD4+, and CD8+ cells in cervic

SUBMITTER: Litwin TR 

PROVIDER: S-EPMC7884592 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature