Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR^mt in the hypothalamus of mice.

ABSTRACT: The maintenance of mitochondrial activity in hypothalamic neurons is determinant to the control of energy homeostasis in mammals. Disturbs in the mitochondrial proteostasis can trigger the mitonuclear imbalance and mitochondrial unfolded protein response (UPR^mt) to guarantee the mitochondrial integrity and function. However, the role of mitonuclear imbalance and UPR^mt in hypothalamic cells are unclear. Combining the transcriptomic analyses from BXD mice database and in vivo experiments, we demonstrated that physical training alters the mitochondrial proteostasis in the hypothalamus of C57BL/6J mice. This physical training elicited the mitonuclear protein imbalance, increasing the mtCO-1/Atp5a ratio, which was accompanied by high levels of UPR^mt markers in t

SUBMITTER: Braga RR 

PROVIDER: S-EPMC7884690 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature