Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice.

ABSTRACT: Reward and motivation deficits are prominent symptoms in many mood disorders, including depression. Similar reward and effort-related choice behavioral tasks can be used to study aspects of motivation in both rodents and humans. Chronic stress can precipitate mood disorders in humans and maladaptive reward and motivation behaviors in male rodents. However, while depression is more prevalent in women, there is relatively little known about whether chronic stress elicits maladaptive behaviors in female rodents in effort-related motivated tasks and whether there are any behavioral sex differences. Chronic nondiscriminatory social defeat stress (CNSDS) is a variation of chronic social defeat stress that is effective in both male and female mice. We hypothesized that CNSDS would reduce effort-r

SUBMITTER: Dieterich A 

PROVIDER: S-EPMC7884699 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature