Injectable hydrogels of newly designed brush biopolymers as sustained drug-delivery vehicle for melanoma treatment.

ABSTRACT: Novel biocompatible and brush copolymers have been developed for cancer treatment using its controlled drug-release potential. Polyurethane graft on linear dextrin has been synthesized to control the hydrophilic-hydrophobic balance for regulated drug delivery. The properties of the graft copolymers have been tuned through graft density. The prepared grafts are thermally stable and mechanically strong. An injectable hydrogel has been developed by embedding the drug-loaded brush copolymers in methyl cellulose to better control the release for a prolonged period, importantly by keeping the drug release at a constant rate. Cellular studies indicate the biocompatible nature of the brush copolymers whose controlled and slow release of drug exhibit significant cytotoxic effects on cancer cells. E

SUBMITTER: Shukla A 

PROVIDER: S-EPMC7884735 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature