Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors.

ABSTRACT: Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly implicated as a mechanism responsible for the metabolic disturbances produced by antipsychotic drugs (APDs). Critically, however, the mechanisms by which catecholamines modulate pancreatic hormone release are not completely understood. We show that human and mouse pancreatic α- and β-cells express the catecholamine biosynthetic and signaling machinery, and that α-cells synthesize DA de novo. This locally-produced pancreatic DA signals via both α- and β-cell adrenergic and dopaminergic receptors with different affinities to regulate glucagon and insulin rele

SUBMITTER: Aslanoglou D 

PROVIDER: S-EPMC7884786 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature