HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.

ABSTRACT:

Background

Understanding the pathways that drive adrenocortical carcinoma (ACC) is essential to the development of more effective therapies. This study investigates the role of the transcription factor HOXB9 and other HOX factors in ACC and its treatment.

Methods

We used transgenic mouse models to determine the role of Hoxb9 in adrenal tumour development. Patient transcriptomic data was analysed for the expression of HOX genes and their association with disease. Drug response studies on various adrenocortical models were done to establish novel therapeutic options.

Results

Our human ACC dataset analyses showed high expression of HOXB9, and other HOX factors, are associated with poorer prognosis. Transgenic overexpression of Hoxb9 in the adrenal cortex of mice with act

SUBMITTER: Francis JC 

PROVIDER: S-EPMC7884796 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature