Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance.

ABSTRACT: Evasion of immunosurveillance is critical for cancer initiation and development. The expression of "don't eat me" signals protects cancer cells from being phagocytosed by macrophages, and the blockade of such signals demonstrates therapeutic potential by restoring the susceptibility of cancer cells to macrophage-mediated phagocytosis. However, whether additional self-protective mechanisms play a role against macrophage surveillance remains unexplored. Here, we derived a macrophage-resistant cancer model from cells deficient in the expression of CD47, a major "don't eat me" signal, via a macrophage selection assay. Comparative studies performed between the parental and resistant cells identified self-protective traits independent of CD47, which were examined with both pharmacological

SUBMITTER: Chen J 

PROVIDER: S-EPMC7884830 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature