Structural Brain Network Abnormalities and the Probability of Seizure Recurrence After Epilepsy Surgery.

ABSTRACT:

Objective

We assessed preoperative structural brain networks and clinical characteristics of patients with drug-resistant temporal lobe epilepsy (TLE) to identify correlates of postsurgical seizure recurrences.

Methods

We examined data from 51 patients with TLE who underwent anterior temporal lobe resection (ATLR) and 29 healthy controls. For each patient, using the preoperative structural, diffusion, and postoperative structural MRI, we generated 2 networks: presurgery network and surgically spared network. Standardizing these networks with respect to controls, we determined the number of abnormal nodes before surgery and expected to be spared by surgery. We incorporated these 2 abnormality measures and 13 commonly acquired clinical data from each patient into a robust mach

SUBMITTER: Sinha N 

PROVIDER: S-EPMC7884990 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature