Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment.

ABSTRACT: In the continuing search for novel antibiotics, antimicrobial peptides are promising molecules, due to different mechanisms of action compared to classic antibiotics and to their selectivity for interaction with microorganism cells rather than with mammalian cells. Previously, our research group has isolated the antimicrobial peptide LyeTx I from the venom of the spider Lycosa erythrognatha. Here, we proposed to synthesize three novel shortened derivatives from LyeTx I (LyeTx I mn; LyeTx I mnΔK; LyeTx I mnΔKAc) and to evaluate their toxicity and biological activity as potential antimicrobial agents. Peptides were synthetized by Fmoc strategy and circular dichroism analysis was performed, showing that the three novel shortened derivatives may present membranolytic activity, like the

SUBMITTER: Fuscaldi LL 

PROVIDER: S-EPMC7885047 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature