Flagellar Perturbations Activate Adhesion through Two Distinct Pathways in Caulobacter crescentus.

ABSTRACT: Bacteria carry out sophisticated developmental programs to colonize exogenous surfaces. The rotary flagellum, a dynamic machine that drives motility, is a key regulator of surface colonization. The specific signals recognized by flagella and the pathways by which those signals are transduced to coordinate adhesion remain subjects of debate. Mutations that disrupt flagellar assembly in the dimorphic bacterium Caulobacter crescentus stimulate the production of a polysaccharide adhesin called the holdfast. Using a genomewide phenotyping approach, we compared surface adhesion profiles in wild-type and flagellar mutant backgrounds of C. crescentus We identified a diverse set of flagellar mutations that enhance adhesion by inducing a hyperholdfast phenotype and discovered a second

SUBMITTER: Hershey DM 

PROVIDER: S-EPMC7885107 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature