An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion.

ABSTRACT: Diversion of the Legionella pneumophila-containing vacuole (LCV) from the host endosomal-lysosomal degradation pathway is one of the main virulence features essential for manifestation of Legionnaires' pneumonia. Many of the ∼350 Dot/Icm-injected effectors identified in L. pneumophila have been shown to interfere with various host pathways and processes, but no L. pneumophila effector has ever been identified to be indispensable for lysosomal evasion. While most single effector mutants of L. pneumophila do not exhibit a defective phenotype within macrophages, we show that the MavE effector is essential for intracellular growth of L. pneumophila in human monocyte-derived macrophages (hMDMs) and amoebae and for intrapulmonary proliferation in mice. The m

SUBMITTER: Vaughn B 

PROVIDER: S-EPMC7885109 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature