Can the Xpert MRSA/SA BC assay be used as an antimicrobial stewardship tool? A prospective assay validation and descriptive impact assessment study in a South African setting.

ABSTRACT:

Background

Positive blood cultures showing Gram positive cocci in clusters signifies either Staphylococcus aureus or the less-virulent coagulase-negative staphylococci. Rapid identification and methicillin susceptibility determination with the Xpert MRSA/SA BC assay can improve management of S. aureus bloodstream infection and reduce inappropriate antibiotic use.

Methods

We prospectively evaluated the Xpert MRSA/SA BC assay in comparison with culture, on samples referred to our laboratory in the Western Cape, South Africa. We interviewed attending clinicians upon culture result availability, to assess antibiotic choices and estimate potential impact of the assay.

Results

Of the 231 samples included, there was 100% concordance between the Xpert MRSA/SA BC assay and cul

SUBMITTER: Reddy K 

PROVIDER: S-EPMC7885373 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature