Developmental fates of shark head cavities reveal mesodermal contributions to tendon progenitor cells in extraocular muscles.

ABSTRACT: Vertebrate extraocular muscles (EOMs) function in eye movements. The EOMs of modern jawed vertebrates consist primarily of four recti and two oblique muscles innervated by three cranial nerves. The developmental mechanisms underlying the establishment of this complex and the evolutionarily conserved pattern of EOMs are unknown. Chondrichthyan early embryos develop three pairs of overt epithelial coeloms called head cavities (HCs) in the head mesoderm, and each HC is believed to differentiate into a discrete subset of EOMs. However, no direct evidence of these cell fates has been provided due to the technical difficulty of lineage tracing experiments in chondrichthyans. Here, we set up an in ovo manipulation system for embryos of the cloudy catshark Scyliorhinus torazame and labeled the epi

SUBMITTER: Kuroda S 

PROVIDER: S-EPMC7885385 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature