Emergence of nosocomial associated opportunistic pathogens in the gut microbiome after antibiotic treatment.

ABSTRACT:

Introduction

According to the Centers for Disease Control's 2015 Hospital Acquired Infection Hospital Prevalence Survey, 1 in 31 hospital patients was infected with at least one nosocomial pathogen while being treated for unrelated issues. Many studies associate antibiotic administration with nosocomial infection occurrence. However, to our knowledge, there is little to no direct evidence of antibiotic administration selecting for nosocomial opportunistic pathogens.

Aim

This study aims to confirm gut microbiota shifts in an animal model of antibiotic treatment to determine whether antibiotic use favors pathogenic bacteria.

Methodology

We utilized next-generation sequencing and in-house metagenomic assembly and taxonomic assignment pipelines on the fecal microbiota of

SUBMITTER: Raplee I 

PROVIDER: S-EPMC7885457 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature