Serum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients.

ABSTRACT:

Background

Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in HCC bone metastasis.

Methods

The expression levels of lnc34a in serum samples from 157 HCC patients were detected by quantitative real-time polymerase chain reaction (PCR). Univariate analysis and multivariate analysis were performed to determine statistically significant variables.

Results

Expression levels of lnc34a in serum from HCC patients with bone metastasis were significantly higher than those without bone metastasis. The high expressions of lnc34a, vascular invasion and Barcelona Clinic Liver Cancer (BCLC) stage were associated with bone metast

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7885499 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature