Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline.

ABSTRACT:

Background

Strokes are becoming less severe due to increased numbers of intensive care units and improved treatments. As patients survive longer, post-stroke cognitive impairment (PSCI) has become a major health public issue. Diabetes has been identified as an independent predictive factor for PSCI. Here, we characterized a clinically relevant mouse model of PSCI, induced by permanent cerebral artery occlusion in diabetic mice, and investigated whether a reliable biomarker of PSCI may emerge from the kynurenine pathway which has been linked to inflammatory processes.

Methods

Cortical infarct was induced by permanent middle cerebral artery occlusion in male diabetic mice (streptozotocin IP). Six weeks later, cognitive assessment was performed using the Barnes maze, hippocampi

SUBMITTER: Cogo A 

PROVIDER: S-EPMC7885563 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature