Flavors Enhance Nicotine Vapor Self-administration in Male Mice.

ABSTRACT:

Introduction

Although the use of combustible cigarettes has decreased in many urban regions of America, the use of electronic nicotine delivery systems (ENDS) has dramatically increased. ENDS, or electronic cigarettes (e-cigarettes), differ from combustible cigarettes given that there are no restrictions on flavorant additives in e-liquids. With 95% of ENDS users vaping flavored e-liquids, it is critical to understand how flavors alter vaping-related behaviors. We have previously shown that menthol and green apple flavors enhance nicotine reward-related behavior in a mouse model and in the present study have investigated how menthol and green apple flavors alter e-Vape self-administration behavior in male mice.

Methods

Adult C57/BL6J male mice were used in vapor-inhalation s

SUBMITTER: Cooper SY 

PROVIDER: S-EPMC7885783 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature