Bifurcated monocyte states are predictive of mortality in severe COVID-19.

ABSTRACT: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection presents with varied clinical manifestations¹, ranging from mild symptoms to acute respiratory distress syndrome (ARDS) with high mortality^2,3. Despite extensive analyses, there remains an urgent need to delineate immune cell states that contribute to mortality in severe COVID-19. We performed high-dimensional cellular and molecular profiling of blood and respiratory samples from critically ill COVID-19 patients to define immune cell genomic states that are predictive of outcome in severe COVID-19 disease. Critically ill patients admitted to the intensive care unit (ICU) manifested increased frequencies of inflammatory monocytes and plasmablasts that were also associated with ARDS not due to COVID-19.

SUBMITTER: Cillo AR 

PROVIDER: S-EPMC7885916 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature