Dysregulated gene-associated biomarkers for Alzheimer's disease and aging.

ABSTRACT: Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative disorder with a hidden onset, including difficult early detection and diagnosis. Nevertheless, the new crucial biomarkers for the diagnosis and pathogenesis of AD need to be explored further. Here, the common differentially expressed genes (DEGs) were identified through a comprehensive analysis of gene expression profiles from the Gene Expression Omnibus (GEO) database. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that these DEGs were mainly associated with biological processes, cellular components, and molecular functions, which are involved in multiple cellular functions. Next, we found that 9 of the 24 genes showed the same regulatory changes in the bloo

SUBMITTER: Li M 

PROVIDER: S-EPMC7885957 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature