Statistical considerations for medication adherence research.

ABSTRACT:

Objective

Medication non-adherence is a widespread problem and has been known to be associated with worse health outcomes and increased healthcare costs. Although many measures of adherence have been developed, their usage is not consistent across studies. Furthermore, statistical methods for analyzing adherence measures have not been rigorously evaluated.

Methods

Using Proportion of Days Covered (PDC), a commonly used adherence measure, we examine the variability inherent to study inclusion criteria and several variations of the PDC calculation method using a motivating data example. We illustrated via sensitivity analyses the potential for flawed inference when modeling PDC as an outcome measure. We also performed simulation studies to investigate the statistical pr

SUBMITTER: DeClercq J 

PROVIDER: S-EPMC7886011 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature