Decreased serum creatinine levels predict short survival in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To explore the associations between serum creatinine and creatine kinase (CK) levels with survival in male and female ALS patients.

Methods

A prospective cohort study was carried out including 346 ALS patients with repeated serum creatinine and CK measurements. Kaplan Meier analysis and multivariable Cox regression were used to perform survival analysis.

Results

There were 218 male and 128 female patients, and the males had significantly higher baseline serum creatinine and CK levels than females. After multivariable Cox regression analysis, lower baseline serum creatinine levels were associated with a short survival in both male (≤61 μmol/L, HR: 1.629; 95%CI: 1.168-2.273) and female ALS patients (≤52 μmol/L, HR: 1.677; 95%CI: 1.042-2.699), whereas, the seru

SUBMITTER: Guo QF 

PROVIDER: S-EPMC7886033 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature