Design of a virtual longitudinal observational study in Parkinson's disease (AT-HOME PD).

ABSTRACT:

Objective

The expanding power and accessibility of personal technology provide an opportunity to reduce burdens and costs of traditional clinical site-centric therapeutic trials in Parkinson's disease and generate novel insights. The value of this approach has never been more evident than during the current COVID-19 pandemic. We sought to (1) establish and implement the infrastructure for longitudinal, virtual follow-up of clinical trial participants, (2) compare changes in smartphone-based assessments, online patient-reported outcomes, and remote expert assessments, and (3) explore novel digital markers of Parkinson's disease disability and progression.

Methods

Participants from two recently completed phase III clinical trials of inosine and isradipine enrolled in Assessing

SUBMITTER: Schneider RB 

PROVIDER: S-EPMC7886038 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature