Amyloid-β, cortical thickness, and subsequent cognitive decline in cognitively normal oldest-old.

ABSTRACT:

Objective

To investigate the relationship between amyloid-β (Aβ) deposition and markers of brain structure on cognitive decline in oldest-old individuals with initial normal cognition.

Methods

We studied cognitive functioning in four domains at baseline and change over time in fifty-seven cognitively intact individuals from the EMIF-AD 90+ study. Predictors were Aβ status determined by [¹⁸ F]-flutemetamol PET (normal = Aβ - vs. abnormal = Aβ+), cortical thickness in 34 regions and hippocampal volume. Mediation analyses were performed to test whether effects of Aβ on cognitive decline were mediated by atrophy of specific anatomical brain areas.

Results

Subjects had a mean age of 92.7 ± 2.9 years, of whom 19 (33%) were Aβ+. Compared to Aβ-, Aβ+ individuals sh

SUBMITTER: Pelkmans W 

PROVIDER: S-EPMC7886045 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature